Anesthesia for robotic HITHOC surgery in a patient with pulmonary sarcoma: case report and literature review
Gabriel José Redondano Oliveira
Abstract
Hyperthermic intrathoracic chemotherapy (HITHOC) combined with cytoreductive surgery is an emerging treatment for selected pleural malignancies but poses major anesthetic challenges related to hyperthermia, one-lung ventilation, hemodynamic instability, and cisplatin-associated nephrotoxicity. The anesthetic management of robotic-assisted HITHOC remains poorly described. We report the perioperative management of a 61-year-old man with pulmonary metastatic leiomyosarcoma who underwent robotic cytoreductive surgery followed by HITHOC. Advanced hemodynamic monitoring, lung-protective ventilation, deep neuromuscular blockade, goal-directed fluid therapy, and nephroprotective strategies were used throughout the procedure. The patient remained hemodynamically stable without major intraoperative complications or postoperative renal dysfunction. This case highlights important anesthetic considerations for robotic HITHOC and emphasizes the role of individualized monitoring and multidisciplinary perioperative management in complex thoracic oncologic surgery.
Keywords
References
1. Unigarro-Londoño F, Navarro-Ripoll R, Sánchez-Lorente D, Molins L. Perioperative anaesthetic management of patients undergoing thoracic cytoreductive surgery and HITHOC. Ann Transl Med. 2021;9(11):956. https://doi.org/10.21037/atm-20-6221. PMid:34350271.
2. Kim HJ, Lee HJ, Kim E, Yun J. Abrupt Hemodynamic Changes Accompanying Intrapleural Hyperthermic Chemotherapy: Case Series. Medicine. 2018;97(25):e11138. PMID: 29923981.
3. Markowiak T, Kerner N, Neu R, Potzger T, Grosser C, Ried M. Adequate nephroprotection reduces renal complications after hyperthermic intrathoracic chemotherapy. J Surg Oncol. 2019;120(8):1330-1336. doi:10.1002/jso.25726.
4. Romano G, Zirafa CC, Ceccarelli I, Elia G, Davini F, Melfi F. Update in the treatment of pleural tumors: robotic surgery combined with hyperthermic intrathoracic chemotherapy. Cancers (Basel). 2024;16(9):1691. https://doi.org/10.3390/cancers16091691. PMid:38730643.
5. Baron E, Xu Z, Paro A, Nikiforchin A, Singh RR, Wernberg JA, et al. Robotic versus open cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score-matched study. Surg Endosc. 2026;40(3):2304-12. https://doi.org/10.1007/s00464-025-12494-7. PMid:41444831.
6. Daghmouri MA, Coutrot M, Baekgaard J, Dudoignon E, Hakkakian K, Ponsin M, et al. Perioperative management of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a state of the art. Minerva Anestesiol. 2025;91(12):1205-16. PMid:41542732.
7. Raspé C, Flöther L, Schneider R, Bucher M, Piso P. Best practice for perioperative management of patients with cytoreductive surgery and HIPEC. Eur J Surg Oncol. 2017;43(6):1013-27. https://doi.org/10.1016/j.ejso.2016.09.008. PMid:27727026.
8. Raspe C, Piso P, Wiesenack C, Bucher M. Anesthetic management in patients undergoing hyperthermic chemotherapy. Curr Opin Anaesthesiol. 2012;25(3):348-55. https://doi.org/10.1097/ACO.0b013e32835347b2. PMid:22517311.
9. Rooks CO, Hughes T, Rodgers S, Brister K, Christopher WO, Orr WS. Robotic cytoreductive surgery with heated intraperitoneal chemotherapy. Am Surg. 2023;89(8):3476-7. https://doi.org/10.1177/00031348231161709. PMid:36868581.
10. Kaya A, Karahan MA. Retrospective evaluation of anesthesia management and clinical outcomes in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. BMC Anesthesiol. 2025;25(1):369. https://doi.org/10.1186/s12871-025-03241-5. PMid:40739475.
11. Schmidt C, Creutzenberg M, Piso P, Hobbhahn J, Bucher M. Peri-operative anaesthetic management of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. Anaesthesia. 2008;63(4):389-95. https://doi.org/10.1111/j.1365-2044.2007.05380.x. PMid:18336490.
12. Bezu L, Raineau M, Deloménie M, Cholley B, Pirracchio R. Haemodynamic MDHIC: a systematic review. Anaesth Crit Care Pain Med. 2020;39(4):531-42. https://doi.org/10.1016/j.accpm.2020.03.019. PMid:32320757.
13. Eng OS, Dumitra S, O’Leary M, et al. Association of Fluid Administration With Morbidity in Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy. JAMA Surg. 2017;152(12):1156-1160. PMID: 28813550.
14. Schluermann CN, Hoeppner J, Benk C, Schmidt R, Loop T, Kalbhenn J. Intra-abdominal pressure, cardiac index and vascular resistance during hyperthermic intraperitoneal chemotherapy: a prospective observational Study. Minerva Anestesiol. 2016;82(2):160-9. PMid:25971283.
15. Luzzi L, Franchi F, Dapoto A, Ghisalberti M, Corzani R, Marrelli D, et al. Hyperthermic intrathoracic chemotherapy after extended pleurectomy and decortication for malignant pleura mesothelioma: an observational study on outcome and microcirculatory Changes. J Thorac Dis. 2018;10(S2, Suppl 2):S228-36. https://doi.org/10.21037/jtd.2018.01.10. PMid:29507790.
16. Gupta S, Glezerman IG, Inker LA, Leaf DE. Intravenous Magnesium and Cisplatin-Associated Acute Kidney Injury. JAMA Oncol. 2025;11(6):e250556.
17. Nieto-Elizalde J, Zaballos M, Canal MI, Cabezuelo Markaide E, Power Esteban M, Cabrerizo P, et al. Protective Effect of Diuresis During Hyperthermia on Acute Kidney Injury in Cytoreductive Surgery With HIPEC. Ann Surg Oncol. 2026;33(7):6146-55. https://doi.org/10.1245/s10434-026-19492-6. PMid:41882263.
Submitted date:
09/27/2024
Accepted date:
05/15/2026
